Howard Smithline, M.D.


Research Interests

My research interests broadly involve the diagnosis and treatment of critically ill patients (congestive heart failure, sepsis, myocardial ischemia, cardiac arrest, and cerebral ischemia) in the Emergency Department. 


Current Research

My current research is studying the role nicotinic adenine dinucleotide (NAD) on glycolysis and oxidative phosphorylation in leukocytes of patients with congestive heart failure.  This work is being conducted collaboratively with Dr. Nagendra Yadava.

I am also studying the measurement of nicotinic adenine dinucleotide (NAD), its relationship to oxidative phosphorylation, as well as the pharmacodynamics of supplemental nicotinamide riboside (a NAD precursor) in skeletal muscle, heart, and brain using noninvasive magnetic resonance spectroscopy. This work is being conducted collaboratively with Dr. Rajakumar Nagarajan.


Research Affiliations/Collaborations

  • Pioneer Valley Life Science Institute (PVLSI),
  • Institute of Applied Life Sciences (IALS) at the University of Massachusetts (Amherst),
  • Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL),
  • The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN),
  • The New England Research Directors (NERD) network,
  • Tufts Clinical and Translational Science Institute (Tufts CTSI)